From the north: A1 highway in the direction of Rome, exit Orvieto, SS71 in the direction of Bolsena, SS2 Cassia and SS74 in the direction of Pitigliano.
From the south: Grande Raccordo Anulare towards Florence. Once in Rome, take the A1 highway to the Orte exit, follow the signs for Viterbo, then the SS74 in the direction of Pitigliano.
From Rome: Rome-Civitavecchia highway, then follow the signs for Grosseto-Livorno, Albinia exit, signs for Manciano and then signs for Pitigliano.
From Genoa: A1 highway towards Rome, exit at Albinia and continue along the SS74 towards Pitigliano.
It is possible to reach Pitigliano by bus with daily connections from Siena, Florence and Grosseto, with the Tiemme line for Tuscany and from Viterbo with the Cotral line.